Regulatory T Cells in Colorectal Cancer

One of the essential protection mechanisms of immune system is Treg cells which play an important role in maintenance ofimmune homeostasis. However, they may also inhibit immune functions against tumor cells. It has been reported that Treg cellsare increased in patients suffering from different types of cancer. Increased number of Treg cells has been shown in tumor lymphnodes, peripheral blood, and tumor sites of patient with Colorectal Cancer (CRC). However, it is clear that Treg cells are increased inCRC patients, but the prognostic impact of Treg cells in CRC patients is a matter of debate. It seems that the function of these cellsdepend on the stage of CRC development. The aim of the present review article is to make an attempt to provide vision on the roleof Treg in CRC. Finally, the potential approaches for the treatment of CRC are discussed.